In vitro models for CNS research optimization               CNS DISEASES STATE-OF-THE-ART             Many potential drug candidates cannot be used for the treatment of Central Nervous System           (CNS) diseases since they do not reach therapeutic concentrations in the brain at acceptable          doses. Tough multiple factors influence the amount of drug that eventually reach active sites         in the brain, one of the most important is transport accross the Blood-Brain Barrier (BBB).          IN VITRO TECHNOLOGIES       CELLIAL Technologies has a unique competence in BBB research and provides a variety of       in vitro BBB models (Bovine, Mouse) as well as human neuronal and glial cell cultures, which can      be customized to suit your profiling requirements in terms of e.g. permeability, molecular pharmacology     and target validation.     SOLUTIONS  In a single outsourcing step, CELLIAL Technologies can accelerate your CNS profiling and identify qualified leads candidates and eliminates this botleneck from your discovery process. Quality, flexibility and expertise of offers are the basis of the confidence of our clients.